La vaca

Helicobacter pylori vacuolating cytotoxin, VacA.

Helicobacter pylori is the leading bacterial cause of food-borne illness worldwide and plays a major role in the development of chronic gastritis, peptic ulcer, and gastric cancer. Strains isolated from patients contain the cagA gene (cytotoxin-associated gene A) and produce the vacuolating cytotoxin, VacA. Recent molecular and cellular studies of VacA action have begun to unravel its structure...

Etude sur la digestion pancratique de la caseine pour la production de la toxine tetanique

Potent neutralization of vacuolating cytotoxin (VacA) of Helicobacter pylori by immunoglobulins against the soluble recombinant VacA.

BACKGROUND The recombinant vacuolating cytotoxin (rVacA) of Helicobacter pylori that retains native conformational epitopes was evaluated as a vaccine antigen for anti-H. pylori treatment. METHODS s1m1 vacA gene fraction encoding the mature VacA protein was expressed as a soluble protein in E. coli at low temperature. The efficacy of anti-rVacA antibody against VacA or H. pylori was assessed ...

La lutte contre la Fasciolose en Iran

Seroprevalence of CagA and VacA antibodies

different digestive diseases, such as gastritis, gastric and duodenal ulcer, and mucosa-associated changes to lymphoma and gastric cancer in adults.1 The reasons for developing one or another disease are not well understood and several factors are possibly involved.2 Some virulence genes of H. pylori infection, CagA and VacA, have been shown to influence the clinical outcome of infection in adu...